High-Throughput Nonlinear Optical Microscopy
نویسندگان
چکیده
منابع مشابه
High-throughput nonlinear optical microscopy.
High-resolution microscopy methods based on different nonlinear optical (NLO) contrast mechanisms are finding numerous applications in biology and medicine. While the basic implementations of these microscopy methods are relatively mature, an important direction of continuing technological innovation lies in improving the throughput of these systems. Throughput improvement is expected to be imp...
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Therapeutic treatment of central nervous system pathologies, such as spinal cord injuries, brain trauma, stroke, and neurodegenerative disorders, will greatly benefit from the discovery of small molecules that enhance neuronal growth after injury. Identification of a diverse repertoire of such molecules and of their cellular targets can also provide important tools for fundamental investigation...
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We describe a high-throughput hyperspectral microscope. The system replaces the slit of conventional pushbroom spectral imagers with a static coded aperture mask. We present the theoretical underpinnings of the aperture coded spectral engine and describe two proof-of-concept experimental implementations. Compared to a conventional pushbroom system, the aperture coded systems have 32 times great...
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OBJECTIVE To assess the ability of nonlinear optical microscopy (NLOM) to image ex vivo healthy and degenerative bovine articular cartilage. METHOD Fresh bovine femoral-tibial joints were obtained from an abattoir. Articular cartilage specimens were harvested from the tibial plateau. Normal and degenerative specimens were imaged by NLOM and subsequently fixed and processed for histological ex...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.08.051